Analysis
Accurate mass confirmation and purity assessment on every oligo
Analysis at ATDBio
All oligos are checked by UPLC-MS as standard to confirm identity and purity with UPLC-MS reports available on request
In addition to our standard quality control procedures, tailored analytical support is available for challenging oligonucleotides, heavily modified sequences and project-specific analytical requirements.
Analytical Services at a Glance
Combination of CE and UPLC-MS
Capillary electrophoresis (CE) and UPLC-MS provide a powerful orthogonal analytical approach for oligonucleotide characterisation. While UPLC-MS separates molecules based on chromatographic interactions and provides highly accurate mass confirmation, CE separates oligonucleotides according to their electrophoretic mobility and charge-to-size ratio.
Because the two techniques rely on fundamentally different separation mechanisms, they often reveal complementary information that may not be apparent using a single analytical method alone. Together, CE and UPLC-MS provide greater confidence in oligonucleotide identity, purity and product quality, making them particularly valuable for the analysis of challenging sequences and complex modifications.
Mass confirmation, impurity profiling and purity assessment.
High-resolution separation based on electrophoretic mobility.
Enhanced characterisation of oligonucleotide identity, purity and quality.
Independent Oligonucleotide Analysis
Standalone Analysis Service
ATDBio also offers UPLC-MS analysis as a standalone service for customer-supplied oligonucleotides. Simply send your sample to us and we will provide a detailed UPLC-MS report, typically within one working day of receipt.Modification Assessment
UPLC-MS can be used to verify the successful incorporation of oligonucleotide modifications. By synthesising test oligonucleotides containing the modification of interest, we can confirm successful incorporation and provide analytical data to support modification evaluation and product developmentWhy Choose ATDBio?
- Independent analysis of customer-supplied oligonucleotides
- Detailed UPLC-MS reports with molecular mass confirmation and purity assessment
- Rapid turnaround, typically within one working day of sample receipt
- Scientist-to-scientist technical support from experienced oligonucleotide chemists
- Expertise in challenging, highly modified and difficult-to-characterise oligonucleotides
- Modification assessment to verify successful incorporation of dyes, quenchers and other oligonucleotide modifications
Get in touch to discuss your analytical needs
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