Nucleic Acids Book

A free online book on the chemistry and biology of nucleic acids, for anyone working with or with an interest in nucleic acids in chemistry and biology.

Chapter 1

Nucleic acid structure

Chapter 2

Transcription, Translation and Replication

Chapter 3

Mutagenesis and DNA repair

Chapter 4

Nucleic acid-drug interactions

Chapter 5

Solid-phase oligonucleotide synthesis

Chapter 6

RNA oligonucleotide synthesis

Chapter 7

Purification and characterisation of oligonucleotides

Chapter 8

Synthesis and applications of chemically modified oligonucleotides

Chapter 9

Synthesis and properties of fluorescent oligonucleotides

Chapter 10

Sequencing, forensic analysis and genetic analysis

Chapter 11

Nucleic acid analogues

Chapter 12

Oligonucleotides as drugs