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Nucleic Acids Book

A free online book on the chemistry and biology of nucleic acids, written by Prof. Tom Brown and Dr Tom Brown (Jnr). The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab.

Nucleic acid structure
Transcription, Translation and Replication
Mutagenesis and DNA repair
Nucleic acid-drug interactions
Solid-phase oligonucleotide synthesis
RNA oligonucleotide synthesis
Purification of oligonucleotides
Synthesis and applications of chemically modified oligonucleotides
Synthesis and properties of fluorescent oligonucleotides
Sequencing, forensic analysis and genetic analysis
Nucleic acid analogues
Oligonucleotides as drugs

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  • Oligo calculator

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  • Oligo synthesis: Custom DNA oligonucleotides
  • Common modifications
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  • Large-scale oligo synthesis
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  • Oligonucleotide analogues

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School of Chemistry
University of Southampton
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Nucleic Acids Book

  • Nucleic acid structure
  • Transcription, Translation and Replication
  • Mutagenesis and DNA repair
  • Nucleic acid-drug interactions
  • Solid-phase oligonucleotide synthesis
  • RNA oligonucleotide synthesis
  • Purification of oligonucleotides
  • Synthesis and applications of chemically modified oligonucleotides
  • Synthesis and properties of fluorescent oligonucleotides
  • Sequencing, forensic analysis and genetic analysis
  • Nucleic acid analogues
  • Oligonucleotides as drugs

Modifications

  • Aminolink modification
  • Epigenetic modifications
  • Phosphate modification
  • Thiol-modified oligonucleotides

Fluorescent dyes

  • ATTO dyes
  • Alexa® dyes
  • BODIPY® dyes
  • Collisional fluorescence quenchers: Dabcyl and others
  • Cyanine dyes
  • FAM (fluorescein), HEX, JOE, ROX, TAMRA, TET, Texas Red® and others
  • FRET fluorescence quenchers
  • Fluorescent base analogues
  • LightCycler® dyes
  • Other fluorescent dyes
  • Yakima Yellow

Other articles

  • Analytical methods
  • Base flipping
  • Click chemistry and nucleic acids
  • DNA duplex stability
  • Epigenetics
  • Gene synthesis
  • Next generation sequencing
  • Nucleic acid aptamers
  • Storage of oligonucleotides
  • Molecular weight and mass
  • Ultraviolet absorbance of oligonucleotides

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