Nucleic Acids Book

A free online book on the chemistry and biology of nucleic acids, written by Prof. Tom Brown and Dr Tom Brown (Jnr). The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab.

Nucleic acid structure
Transcription, Translation and Replication
Mutagenesis and DNA repair
Nucleic acid-drug interactions
Solid-phase oligonucleotide synthesis
RNA oligonucleotide synthesis
Purification of oligonucleotides
Synthesis and applications of chemically modified oligonucleotides
Synthesis and properties of fluorescent oligonucleotides
Sequencing, forensic analysis and genetic analysis
Nucleic acid analogues
Oligonucleotides as drugs